I needed to make not one, but 2 characters turn their heads round and look off into the distance. No way was I handdrawing the keyframes, so I came up with a cunning plan.
Im going to explain it briefly, if enough people want an indepth how two, then I shall write one and post it on the boards or my website.
This process takes about 2 hours to setup start to finish. That might sound long, but it is very much worth it. After wards, you will have much much much better facial/lipsync animation then you can achieve with moho and papaygo.
here goes then..
1. Use a 3d app (3dsmax, blender(blender is free!!)) to model and rig a 2d head. *hears gasps from reader* ok ok...calm down. its really not that hard. Once you have the model it will take literally an hour to rig it. Make the eyes and mouth seperate ELEMENTS. not seperate objects, ELEMENTS. This is specific to 3ds max, dont know about other apps. The morpher tool works by morphing the vertex positions, and if you model the eyes and head seperate it cant work properly.
2. To make the head turn, you need to make two morph targets. One were you create the motion of the head turning. Copy this one, but move the mouth and eyes right off the face !!

3. Use after effects or similar to layer the two animations ontop of each other, and mask the part were the eyes slide off the face. This will have the apperance of the head turning 90 degrees, ending up with the back of the head towards the camera.
4. Export this from after effects and Quicktime file making sure u choose the animation profile and millions+ colors. this is vital, since it will store and alpha channel in the quicktime movie.
5. Set up your chrachter in Moho as per the help file that comes with it, but use the quicktime movie as the head!
6 *OPTIONAL* if you got through all that ok, you can try loading a sound file into 3dsmax and lypsyncing your 2d character head to it.
There is an example of this on my showreel....the two chrachters that wave at the bus have been made in this way.
http://www.jamessteel.co.uk/SHOWREEL.wmv
Happy animating!